IDEAYA Biosciences has submitted an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) for the initiation of a Phase 1 clinical trial to evaluate IDE397, a small molecule methionine adenosyltransferase 2a (MAT2A) inhibitor, for the treatment of patients having solid tumors with methylthioadenosine phosphorylase (MTAP) deletion.
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"The IDE397 IND submission is an important milestone for IDEAYA as we advance our broader synthetic lethality pipeline of potential first-in-class therapies. IDE397 was discovered through our efforts to develop a potential best-in-class MAT2A inhibitor, and we have achieved our target product profile," said Michael Dillon, Ph.D., Chief Scientific Officer, IDEAYA Biosciences. "IDE397 is highly selective and active in the MTAP-deletion setting, which represents approximately 15% of all solid tumors, and we are excited about the potential impact IDE397 can make for these patients," said Yujiro S. Hata, Chief Executive Officer, IDEAYA Biosciences.