Intravacc announced that it has been awarded a funding that may total US$ 633K from CARB-X (Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator) a global non-profit organisation, for the development of a preventive vaccine against Neisseria gonorrhoeae (NG). This vaccine will be developed on Intravacc’s proprietary outer membrane vesicle (OMV) platform technology.
The Neisseria gonorrhoeae bacterium causes gonorrhea, the second most reported bacterial STI. Approximately 82 million people were infected globally in 2020. Patients with gonorrhea can face serious health effects, including pelvic inflammatory disease, chronic pain, infertility, and an increased risk of contracting HIV. If left untreated, gonorrhea can spread to the bloodstream, which can be fatal. Since patients do not always exhibit symptoms, reported cases may only capture a fraction of the true burden.
The CARB-X award supports the development of Intravacc’s meningococcal outer membrane vesicle (OMV) vaccine that carries several important gonococcal antigens aimed to prevent infections by Neisseria gonorrhoeae (gonococci). Through the tailored gonococcal antigens on the surface of the meningococcal OMV, Intravacc anticipates a significant enhancement in the vaccine candidate’s efficacy against gonorrhea.
CARB-X funding for this research is supported by federal funds from the U.S. Department of Health and Human Services; Administration for Strategic Preparedness and Response; Biomedical Advanced Research and Development Authority; under Agreement number: 75A50122C00028, and by awards from Wellcome (WT224842), Germany’s Federal Ministry of Education and Research (BMBF), the UK Global Antimicrobial Resistance Innovation Fund (GAMRIF) funded by the UK Government Department of Health and Social Care (DHSC), and the Bill & Melinda Gates Foundation. The content of this press release is solely the responsibility of the authors and does not necessarily represent the official views of any CARB-X funders.
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