Accelerating mRNA-based Therapy Development with Scalable Purification of In-Vitro Transcribed mRNA

The potential of mRNA in therapies seems to be endless but obtaining larger quantities of synthetic mRNA for clinical treatment remains a challenge. The current available methods for mRNA purification are becoming a bottleneck in large-scale manufacturing. Affinity chromatography, a highly scalable method, has earned its credits in the development of biologics. An effective affinity purification step can help to simplify downstream processing, reduce the number of purification steps and reduce the overall cost of goods in bio-therapeutic Manufacturing.

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