![[Article Title]](https://media.americanpharmaceuticalreview.com/m/28/article/622535-134x100.jpg)
The pharmaceutical industry is shifting from traditional horseshoe crab blood-based LAL testing to sustainable, animal-free alternatives for endotoxin detection. In this exclusive interview, Charles River Labs' Product Manager Courtney Wachtel discusses key regulatory milestones—including the landmark USP Chapter <86> guidance from May 2025—and how recombinant testing methods are gaining global traction. She also reveals an innovative cartridge recycling program that addresses plastic waste while maintaining validated workflows. Learn about the challenges still facing full industry adoption, customer feedback on these sustainability initiatives, and what the next decade holds for harmonizing patient safety with environmental responsibility.