The purpose of this column is to highlight and summarize recent key patents in the pharmaceutical arena issued by the US Patent Office in January-February, 2024.
Determining the Status of an Injection;
M. Helmer; Sanofi, Paris, France; U.S. Patent # 11,878,152; January 23, 2024.
The system includes an injection device and an electronic device. The injection device comprises a housing with at least one cylindrical surface, a first coil in the housing of the electronic device which produces a voltage pulse indicative of a first status of the injection device as a first Wiegand wire of the injection device moves from a first position proximate to a first magnet to a second position proximate to a second magnet. Wiegand wire is a low-carbon ferromagnetic alloy of cobalt, iron, and vanadium. Such a device governs the start time of an injection, the end time of an injection, and the hold time of the injection.
Process for Preparing a Drug Delivery Composition;
P. Pouletty and F. Guillamot; PK Med, Paris, France; U.S. Patent # 11,911,476; February 27, 2024.
Drug delivery systems are complex, one such system is using hot melt extrusion (HME). In this system, high temperature is used, which may not be suitable for some drugs. If the dose is small, it is difficult to disperse the drug uniformly. In general, large amounts of drugs can’t be loaded in HME products. A masterbatch is prepared with the first polymer, where the drug molecular mass is about 15 kDa, and the drug loading is about 60%. The polymer is melted at about 140°C and the batch is prepared by extrusion. The masterbatch is introduced in a polymer-based matrix at temperature, which melts both the masterbatch and the polymer matrix.
Topical Skin Compositions for Treating Wrinkles;
T. Florence, M. Hines, D. Gan, and W. Zhao; Mary Kay, Inc., US; U.S. Patent # 11,911,494; February 27, 2024
Aging, exposure to toxic environments, malnutrition, etc. affect the appearance of skin and the formation of wrinkles. A topical product was invented, which includes Commiphora mukul resin or extract thereof, hyaluronic acid, ornithine, retinol, etc. Guggul is the gum resin obtained from Commiphora mukul. Guggul contains a mixture of plant compounds – steroids, essential oils, lignans, flavonoids, etc. It has anti-inflammatory and antioxidant properties. Commiphora mukul fills the wrinkle creases and hyaluronic acid attracts water to the wrinkle. Retinol and ornithine are believed to treat the underlying causes of wrinkle formation.
Time Release Sleep Aid System;
D. Rinaldi and S. Forsberg; NightWise LLC, Norcross, US; U.S. Patent # 11,890,271; February 6, 2024.
Sleep disorders such as insomnia can lead to various medical problems. As a result, numerous methods and remedies have been created. Compositions are for sleep promotion, sleep quality, and sleep recovery. These compositions can provide an immediate burst release of sleep-promoting active agents, a delayed sustained release of sleep-quality active agents, and a delayed burst or delayed sustained release of circadian rhythm maintenance agents in a daily oral uni-dosage form. Methods of making and using the compositions have also been provided.
Compositions and Methods of Treatment with Amniotic Fluid;
T. J. Koob and M. Massee; MiMedx Group, Inc., Marietta, USA; U.S. Patent # 11,865,142; January 9, 2024.
Amniotic fluid allows fetal growth and provides mechanical cushioning to the fetus to help growth continue. This fluid also contains nutrients, growth factors, and cells that help the developing fetus move within the womb, promote proper lung development, and regulate the temperature around the fetus, among other functions. The patent relates to the compositions of amniotic fluid, which can be modified or unmodified. The disclosure is also relevant to the treatment of diseases and disorders ranging from skin diseases to pulmonary diseases, etc. This disclosure also involves ways for administering said compositions of amniotic fluid.
Capsule Shell Comprising a Core-Shell Polymer and a Cellulose;
B. Holzer, M. Abmus, and K. Nollenberger; Evonik Operations GmbH, Essen, DE; U.S. Patent # 11,904,056; February 20, 2024.
Hard shell capsules are widely used for oral pharmaceutical dosage forms. Many biologically active ingredients are sensitive to acidic conditions. There is a need for capsules that disintegrate at higher pH conditions in the intestine. This invention describes the different disintegrating profiles for hard shell capsules. A capsule shell contains 40 to 99% of the weight of a core-shell polymer and 1 to 60% by the weight of cellulose. The core-shell polymer contains 50 to 90% by weight of a core, containing polymerized units of 65 to 75% by weight of ethyl acrylate and 25 to 35% by weight of methyl methacrylate; and 10 to 50% by weight of a shell, containing polymerized units of 45 to 55% by weight of ethyl acrylate and 45 to 55% by weight of methacrylic acid.
Compositions and Methods for Treating Diseases of the Nail; G.
Winckle and G.T. Fieldson; Bausch Health Ireland Ltd., Dublin, Ireland; U.S. Patent # 11,872,218; January 16, 2024.
There are various methods and compositions for treating disorders that involve the nail and the nail bed. These treatments, or compositions, contain a vehicle that causes all components or parts of the composition to be dissolved, suspended, dispersed, or emulsified. There is a non-volatile solvent, a wetting agent, and a pharmaceutically active ingredient in this composition. The pharmaceutically active ingredient is soluble in the non-volatile solvent. It can also be soluble in a mixture of the vehicle and the non-volatile solvent. When these factors are present in the composition, the composition is effective in the treatment of the disorder of the nail and nail bed.
Author Details
Neelam Sharma, MS; Lakshmi Lavanya Kundurthy, BE; and Hemant N. Joshi, Ph.D., MBA*- Tara Innovations, LLC, www.tarainnovations.com, *[email protected]
Publication Details
This article appeared in American Pharmaceutical Review:Vol. 27, No. 3April 2024Pages: 70-71
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