Hydroxypropyl Cellulose for Orally Disintegrating Film Drug Application

Hydroxypropyl cellulose (HPC) is a water-soluble polymer that has film formation properties with excellent plasticity. Its hydroxypropyl groups drive the solubilization of the cellulose thus hindering the hydrogen bonding of the hydroxyl groups. In this study, we evaluated the applicability and effectiveness of HPC in Orally Disintegrating Films (ODF’s) by varing the API, excipient and molecular weight of HPC. Based on the results of the evaluation, ODFs could by prepared using HPC as the base material.