Description
Targeted Protein Degradation (TPD) represents a paradigm shift in tackling "undruggable" targets, and our PROTAC Design and Development Service is at the forefront of this field. We utilize structural modeling and advanced ternary complex simulations to optimize the design of Proteolysis-Targeting Chimeras (PROTACs). Our workflows evaluate E3 ligase selection, warhead binding affinity, and linker length/flexibility in silico. This rational design process predicts cooperative binding and spatial orientation, ensuring highly efficient target ubiquitination and degradation.