White Paper: Optimizing the Bio-Rad NGC Chromatography System for Cryo-EM Applications for High-Resolution and Low-Volume SEC

Structural biology is the three-dimensional study of complex biological molecules, like proteins, to determine their structures at
atomic resolution. The structural characterization of complex proteins gives researchers a glimpse into their in-vivo mechanistic functions and complex novel chemistries. In the case of drug development, structural information of proteins involved in disease pathways is crucial for downstream rational design of novel therapeutics. The fi eld of structural biology is currently undergoing a renaissance due to signifi cant advances in cryogenic electron microscopy (cryo-EM) with the emergence of direct electron detectors and advanced computational platforms. Protein structures can now be determined to the near-atomic level using this technique and many researchers are looking to add cryo-EM into their research repertoire.

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