The purpose of this column is to highlight and summarize recent key patents in the pharmaceutical arena issued by the US Patent Office in October-November, 2024.
Increased Bioavailability of Transdermally Delivered Agents; R.F. Ross; Vivasor, Inc., USA; U.S. Patent # 12, 138, 415; November 12, 2024.
A method for delivering a bioactive agent to the cardiovascular system is described. The method delivers the agent at a high bioavailability and with little loss of agent to the natural defense mechanisms of the body. The method includes penetrating the stratum corneum of the subject with a microneedle that is in fluid communication with the bioactive agent. In addition, the microneedle includes a plurality of nanostructures formed on a surface thereof in a pattern, including transporting the bioactive agent through the microneedle and delivering the bioactive agent to the subject. It has a 20% greater bioavailability as compared to the subcutaneous delivery route.
Treatment of Epithelial Cysts by Intracystic Injection of Antineoplastic Particles; G.S. diZerega, M. Baltezor, C.J. Decedue, S. Campbell, M. McClorey, M. Iacobucci, and H. Maulhardt; Crititech, Inc., USA; U.S. Patent # 12,128,131; October 29, 2024.
A cystic neoplasm or cyst is an abnormal sac in the body that may be filled with a liquid or semisolid substance. A cyst can form in any part of the body. Mucinous pancreatic cysts have a malignant potential with the risk of developing cancer. An epithelial cyst has an epithelial inner lining. The patent describes a method of injecting an effective amount of paclitaxel particles into an epithelial cyst along with an aqueous liquid. The cyst fluid is withdrawn from the cyst prior to injection of the drug composition. The volume of drug composition injected in the cyst is equal to the volume of cyst fluid removed from the cyst.
Reduction of Adipose Tissue; J. D. Dobak III, USA; 10Xbio LLC, USA; U.S. Patent # 12,133,836; November 5, 2024.
Procedures for removing fat from the human body have increased in prevalence as the general population has increased in weight and age. Lipoplasty and other surgical methods for removing fat present significant risks including death, high rates of complications, infection, seromas, skin damage, thromboembolism and fluid imbalances. Thus, there is a need for alternative procedures for removal of fat deposits. The patent discusses pharmaceutical compositions, formulations, methods, and systems to reduce regional fat, adipose tissue, adipocyte and regional or localized adiposity. The patent also delves into methods of reducing subcutaneous adipose tissue in a subject in need and the method including administering to the subject a pharmaceutical formulation. The method administers an effective amount of a pharmaceutical formulation including polidocanol and a co-solvent, where it is administered in treatment sessions every 14 days
Small-Molecule Adjuvants for Antibiotics to Address Antibiotic Resistance; M.S. Blackledge, P.A. Vigueira, and H.B. Miller; High Point University, USA; U.S. Patent # 12,115,208; October 15, 2024.
Bacterial biofilms are three-dimensional communities of bacteria. Once such source for biofilm formation is implanted medical devices. Bacteria in the biofilms are significantly more resistant to antibiotics. The disclosed methods and compositions provide a treatment for infections or to prevent biofilm formation. The inventors combined currently available antibiotics with an adjuvant compound. The adjuvant compound comprises of a fused tricyclic ring system with at least one halogen substituent. The method also decreases the minimum inhibitory concentration of the antibiotic.
Hydrocortisone Acetate Suppository Formulation for Treatment of Disease; J. J. Davagian and R. Devrajan; Cristcot LLC, USA; U.S. Patent #12,109,306; October 8, 2024.
Rectally administered hydrocortisone acetate has a lot of benefits and it is useful to treat many conditions. One observes low systemic absorption and fewer side effects with rectal administration. The present formulation mainly contains hydrocortisone acetate and colloidal silicon dioxide. The formulation does not depend on the melting of the suppository and has reduced absorption variability. Another embodiment of the invention is a delivery system that changes the shape once placed in the rectum. One example is a ring shape, which is twisted to form a smaller ring or folded different ways. Once inside, it expands and fits within the rectum.
Author Details
Neelam Sharma, MS, Lakshmi Lavanya Kundurthy, BE and Hemant N. Joshi, Ph.D., MBA, hemantjoshi@tarainnovations.comTara Innovations, LLC, www.tarainnovations.com
Publication Details
This article appeared in American Pharmaceutical Review:Vol. 28, No. 1Jan/Feb 2025Pages: 54-55
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