It can take extensive time and effort to determine the optimum mobile phase conditions and the most suitable column for separation of the analyte among a wide variety of available chiral columns. This has spurred the demand for faster scouting of chiral separation conditions. This report details an example of using the Nexera Method Scouting system with iChiral-6 polysaccharide-based columns (Daicel Corporation), to quickly determine through exhaustive analysis the best column and mobile phase for each of three types of chiral compounds.
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