Description
The Mobius® TFF 80 system with Flexware® Assemblies is a fully automated system designed to enable the clinical and commercial-scale operation of TFF processes for the concentration and diafiltration of monoclonal antibodies (mAbs), vaccines, viral vectors, and therapeutic proteins. The system has the same functionalities as conventional TFF systems, and by incorporating a completely single-use flow path, it provides operational flexibility while eliminating concerns of carryover or cross-contamination.
Large-scale capabilities,
with no compromise on quality
- 500 L and 200 L tanks, with up to 80 L/min
diaphragm pump, and matching flow path design
- Holder for filter area up to 20 m² with Pellicon®
cassettes and 18 m2 with single-use Pellicon®
capsule manifolds
Designed for optimized yield and
product recovery
- Tank geometry and mixing technology ensures product homogeneity, key for product quality during concentration and diafiltration
- Large tank volume to minimum working volume ratio for high concentration factor
- Highly drainable system with the lowest possible unrecoverable volume
Adapts to multi-product and
multi-processing modes
- Single-use sensors and flow path eliminate cleaning requirements and risks for carryover from previous
batches
- Closed mode of operation is possible with a specifically designed flow path and consumables, allowing for reduction of contamination risk while increasing flexibility and operator safety
Fully automated and user friendly
- Full automation with step edition CCP® Software
- Easy cassette installation via the central manifold and hydraulic compression on the holder
- Transparent clamshell design allows visual monitoring of process fluids within the flow path