The drug manufacturing process can be broken down into a variety of operations, which can include granulation, coating, pressing, and milling. During the milling process, mechanical energy is used to physically break down coarse particles to finer particles. This occurs for a number of reasons, which includes increasing bioavailability, dosage uniformity, increasing the solubility of the drug compound, and increasing homogeneity. Fine drug particulates are highly desirable in formulations that are designed for respiratory and transdermal use. Thanks to advancements in technology, production of drug micro- and nano-particles on a commercial scale are widely available to pharmaceutical manufacturers.
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