Description
The Notch signaling pathway controls cell fate decisions in vertebrate and invertebrate tissues. Notch signaling is triggered through the binding of a transmembrane ligand, such as Delta like ligand 4 (DLL4) or jagged 1 (JAG1) to a Notch transmembrane receptor (Notch1, Notch2, Notch3, Notch4) on a neighboring cell. This results in proteolytic cleavage of the Notch receptor, releasing the constitutively active intracellular domain of Notch (NICD). NICD translocates to the nucleus and associates with transcription factors CSL (CBF1, RBPJ?, Suppressor of Hairless, Lag-1) and the coactivator, Mastermind, to turn on transcription of Notch responsive genes