App Note: Study of Protein Conformation with FT-IR

The principle and application range of this technique in the field of protein biochemistry will be examined. Infrared light excites molecules to vibrate. Those molecules absorb only light of certain wavelengths that correspond to any of their specific vibration frequencies. Therefore, the position of the corresponding band in the absorption spectrum is characteristic for a certain vibration and, according to the Lambert-Beer Law, the band intensity is directly proportional to the concentration of the vibrating molecule. Proteins become also even more important as active drugs in pharmaceuticals. Especially therapeutic antibodies are a promising approach for the treatment of diseases that have been incurable so far.

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