Achieving targeted delivery of nucleic acids to specific tissues and cells presents a challenging obstacle in biomedical research and therapeutic development. When engineered specifically, nanoparticles offer a versatile platform for improving the precise delivery of nucleic acid using endogenous mechanisms for a targeted approach. This article provides an overview of the multifaceted approaches to overcome delivery challenges, including the examination of nanoparticle formulations with a specialized emphasis on extrahepatic delivery. Download to learn more.