Drug Delivery Articles - Latest

Since layer-by-layer (LbL) polyelectrolyte assembly was introduced in the nineteen nineties, it has found application in various fields that study and apply nanotechnology. LbL nanoassembly is based on the sequential adsorption of positively and negatively charged polymers on a surface to form a nano-thick film of coating. The process involves resaturation of polyion adsorption, resulting in the reversal of the terminal surface charge of the film after deposition of each layer. The method provides the possibility of designing ultrathin multilayer films with a precision better than one nanometer of defined molecular composition. These films can be applied to surfaces or can be used to coat micro- and nanoparticles. This coating process can be used to control the release of drugs, increase the stability of drugs and to improve the properties of commonly used excipients. Since no covalent binding is involved in the shell formation it allows the drug or excipient to remain intact. Therefor read more

Pre-filled syringes (PFS) are well-established, functional container closure systems for biological products. Examples for marketed biological products available as PFS presentation include monoclonal antibody-based products, cytokines and vaccines [1]. read more

Dissolution technique is an excellent tool for monitoring batch-to-batch quality control and to understand drug release in in-vivo conditions. Dissolution methods are mostly recommended for solid oral dosage forms. read more

The initial focus of container closure testing centred on the containers compatibility with the drug product, ability to accurately deliver the dose and maintain sterility. With the development of a multitude of formulation and container closure combinations, the risk posed by container closures is no longer considered “basic” evolving to focus on the role of packaging components and their interaction with the drug product. read more