Drug Delivery

Drug delivery is the method in which a pharmaceutical compound is administered to promote a therapeutic effect. Drug delivery routes can include oral, transdermal, nasal, and sublingual application and can directly impact a drugs efficacy. In this drug delivery content hub, you can discover editorial coverage of the latest research and industry trends impacting drug delivery and novel drug discovery.

Sharper, Faster, Smarter: The Mass Spectrometry Advantage in Bioanalytical Testing
Drug-plasma protein binding is a fundamental parameter in drug development that directly affects how a compound is distributed, metabolized, and excreted. Only a drug’s unbound fraction is pharmacologically active, so accurate measurements are essential for understanding efficacy and safety. This information also guides dosage design, predicts ... read more
Spray Dried Dispersions in Controlled Release Formulations
The pharmaceutical industry continues to face significant challenges in formulating poorly water-soluble drugs, which constitute most new chemical entities (NCEs).1 Among various solubility-enhancing strategies, amorphous solid dispersion (ASD) is one of the most effective and versatile strategies for enhancing oral bioavailability. ASDs can ... read more
Analytical Method Development with a Practical Risk Assessment Program that Enhances Commercial QC Robustness
Active pharmaceutical ingredient process development requires comprehensive analytical controls utilizing a wide range of analytical methods. An analytical risk survey program was previously developed to evaluate common risk factors in the analytical control strategy for early to mid-stage development. For late-stage and the development of ... read more

cGMP Radiosynthesis for Early Phase Clinical Trials: A Unique Challenge and Development of a Standard Process
Radiolabeled drugs are used in human ADME and bioavailability studies. read more
Detailed Formulation Development Helps Avoid Production Problems
Developing a robust tablet formulation that can be scaled into product manufacturing can be a difficult challenge. read more
Preventing Sticking and Picking Through Tablet Design
Sticking and picking are two common problems encountered in tablet manufacturing. read more
Tool Life Expectancy
Tooling is a significant investment for companies. read more
Contamination Control: Cleaning and Disinfecting Techniques for Controlled Environments
Effective contamination control procedures require high-quality cleaning equipment and specialized techniques. Critical cleaning professionals recommend the use of multi-bucket mopping systems for maximum cleanliness, efficiency and removal of contaminants. read more

Optimizing Lipid Nanoparticles (LNPs) Processing for siRNA Delivery by Microfluidics System
Optimizing lipid nanoparticles (LNPs) processing for siRNA delivery by microfluidics system read more

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