Monday, September 25, 2023

In this webinar, the sticking propensity is investigated using ibuprofen, flurbiprofen, and ketoprofen as model substances with the ultimate goal of estimating the rank order of sticking of drug substances from molecular simulations. It is hypothesized that intermolecular interactions between a drug molecule and a punch face are the first step in the adhesion process, and the rank order of adhesion during tablet compression should correspond to the rank order of the energies of these interactions. The molecular basis of adhesion leading to sticking is investigated by exploring the correlation between thermal analysis and AFM with molecular simulations.

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On-Demand Webinar: On-Demand Webinar: Modeling of Adhesion in Tablet Compression at the Molecular Level Using AFM, Thermal Analysis, and Molecular Simulations