Increased Bioavailability Excipients

Excipients are generally pharmacologically inert, but can interact with drugs in the dosage form and the physiological factors at the site of absorption to affect the bioavailability of a drug product. The use of specific excipients with enhanced bioavailability properties can assist with getting the active ingredient into the bloodstream.

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Product / CompanyFunctionalityApplicationPrice 
Captisol®
Captisol®, A Ligand Technology
Solubilizer, Increased bioavailability, StabilizerImproves solubility, stability, bioavailability and dosing of APIs
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Capryol PGMC
Gattefossé
InquireSolubilizer, Bioavailability enhancer, Water insoluble surfactant for SELF, Solubilizer for actives, W/O surfactant
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CapryolTM 90
Gattefossé
Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, Inhalation products, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aidSolubilizer, Bioavailability enhancer, Co-solvent in capsule filling, Inhalation products, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid
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Gelucire® 44/14
Gattefossé
Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, SpheronizationSolubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization
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Gelucire® 48/16
Gattefossé
Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, SpheronizationSolubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization
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Gelucire® 50/13
Gattefossé
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS). Modulation of drug release. Lipid binder in melt processes.Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Matrix for modified release, Multiparticulates
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Labrafac™ PG
Gattefossé
Oily phase for topical formulations. Oily vehicle and solubilizer for solutions.Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions
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Labrafac™ lipophile WL 1349
Gattefossé
Oily vehicle in LFCS Type I, Type II (SEDDS), and Type III formulations (SMEDDS). Oil phase for topical formulations. Oily vehicle and solubilizer for solutions (parenteral, auricular).Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions, Penetration enhancer
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Labrafil® M 1944 CS
Gattefossé
Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal creamWater dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions
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Labrafil® M 2125 CS
Gattefossé
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS).Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions
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Labrafil® M1944 CS
Gattefossé
Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancerSolubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancer
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Labrasol®
Gattefossé
Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aidSolubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid
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Labrasol®
Gattefossé
Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required).Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Topical penetration/permeation enhancer
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Labrasol® ALF
Gattefossé
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility.Guaranteed for low aldehyde levels. Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Topical penetration/permeation enhancer
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LauroglycolTM 90
Gattefossé
Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aidSolubilizer, Bioavailability enhancer, Co-solvent in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid
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Lauroglycol™ FCC
Gattefossé
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.Water insoluble cosurfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions, Penetration enhancer
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Maisine CC
Gattefossé
Solubilizer for lipophilic API and bioavailability enhancer. Oily vehicle for LFCS Type I (oily), Type II (SEDDS) and Type III (SMEDDS), associated with lymphatic absorption.Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions
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Peceol™
Gattefossé
Solubilizer for lipophilic APIs and bioavailability enhancer. Oily vehicle containing long-chain fatty acids (C18:2) for LFCS Type I (oily), Type II (SEDDS), and Type III (SMEDDS), associated with lymphatic absorption. Oily vehicle for topical formulations.Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF
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Plurol® Oleique CC 497
Gattefossé
Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulations.Water insoluble cosurfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions, Penetration enhancer
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