Lipid Excipients

The use of lipids in sustained release formulations is growing. Lipid excipients delivery the drug by creating an insoluble matrix structure from which diffusion is the principal drug release mechanism. It not only forms a water-insoluble matrix, but provides pH-independent release, non-digestible, highly resistant to physiological conditions, and does not result in alcohol-related dose dumping. Lipid-based drug delivery (LBDD) systems are well suited for poorly water-soluble, lipophilic, hydrophobic APIs. Lipid-based formulations are categorized into four types on the basis of composition, dispersion, and digestion characteristics.

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Product / Company	Functionality	Application	Price
Capryol PGMC Gattefossé	Inquire	Solubilizer, Bioavailability enhancer, Water insoluble surfactant for SELF, Solubilizer for actives, W/O surfactant	Get quote White Paper SDI Phase	Compare or Get quote for selected.
CapryolTM 90 Gattefossé	Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, Inhalation products, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, Inhalation products, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Compritol® 888 ATO Gattefossé	Tablet Lubricant, Lipid Matrix for Sustained Release, Coating for Protection and Taste Masking. Oral Solid Dosage forms in Direct Compression, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization, Supercritical Fluid Extraction, Viscosity modification, Wet Granulation, Solid Lipid Nanoparticles, Nano Lipid Carriers	Tablet Lubricant, Lipid Matrix for Sustained Release, Coating for Protection and Taste Masking. Oral Solid Dosage forms in Direct Compression, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization, Supercritical Fluid Extrac	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Compritol® HD5 ATO Gattefossé	Lubricant and wetting agent in fast-dissolving and effervescent tablets.	Lubricant for effervescent, chewable and fast dissolving tablets	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Geleol™ Mono and Diglycerides NF Gattefossé	Modified release matrix former for capsule. Coating agent for taste masking. Consistency agent.	Semi-solid vehicle, Non-ionic thickener for emulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Geloil™ SC Gattefossé	Vehicle to suspend pharmaceutical ingredients in soft gelatin capsule. Good dispersibility in aqueous fluid. High drug load achievable.	Oil carrier, Consistency agent	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Gelot™ 64 Gattefossé	Emulsifier for difficult-to-formulate APIs, API combinations, anhydrous emulsion. Associate with Emulcire™ 61 WL2659 to enhance sensorial and texture properties.	Non-ionic O/W emulsifier for difficult actives, alcoholic extracts, polar lipids, high heat stability and pH range of 3-12	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Gelucire® 43/01 Gattefossé	Matrix-forming agent for protection of APIs sensitive to oxidation, humidity, or light. Consistency agent in oral and topical formulations.	Vehicle, Matrix former, Sustained release agent, Multiparticulates	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Gelucire® 44/14 Gattefossé	Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization	Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Gelucire® 48/16 Gattefossé	Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization	Solubilizer, Bioavailability enhancer, Surfactant, for Solid Dispersions and SMEDDS in Capsule filling, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Gelucire® 50/13 Gattefossé	Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into coarse emulsion—LFCS Type III (SMEDDS). Modulation of drug release. Lipid binder in melt processes.	Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Matrix for modified release, Multiparticulates	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrafac™ PG Gattefossé	Oily phase for topical formulations. Oily vehicle and solubilizer for solutions.	Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrafac™ lipophile WL 1349 Gattefossé	Oily vehicle in LFCS Type I, Type II (SEDDS), and Type III formulations (SMEDDS). Oil phase for topical formulations. Oily vehicle and solubilizer for solutions (parenteral, auricular).	Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions, Penetration enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrafil® M 1944 CS Gattefossé	Solubilizer for poorly-soluble API and bioavailability enhancer Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion – LFCS type II (SEDDS) Combine with Labrasol®ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS) Co-emulsifier in topical formulations often associated with Tefose® 63 in antifungal cream	Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrafil® M 2125 CS Gattefossé	Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into emulsion—LFCS Type II (SEDDS). Combine with Labrasol® ALF or Gelucire® 44/14 for LFCS Type III (SMEDDS).	Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrafil® M1944 CS Gattefossé	Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancer	Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrasol® Gattefossé	Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required).	Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Topical penetration/permeation enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrasol® Gattefossé	Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Labrasol® ALF Gattefossé	Solubilizer for poorly-soluble APIs and bioavailability enhancer. Single excipient formulation system: self-emulsifies in aqueous fluid into microemulsion—LFCS Type III (SMEDDS). High purity guaranteed for stability and capsule compatibility.	Guaranteed for low aldehyde levels. Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Topical penetration/permeation enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.
LauroglycolTM 90 Gattefossé	Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Solubilizer, Bioavailability enhancer, Co-solvent in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Lauroglycol™ FCC Gattefossé	Solubilizer for poorly-soluble APIs and bioavailability enhancer. Cosurfactant in LFCS Type II (SEDDS) and Type III (SMEDDS) formulations. Solubilizer and cosurfactant for microemulsion in topical formulation.	Water insoluble cosurfactant, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions, Penetration enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Maisine CC Gattefossé	Solubilizer for lipophilic API and bioavailability enhancer. Oily vehicle for LFCS Type I (oily), Type II (SEDDS) and Type III (SMEDDS), associated with lymphatic absorption.	Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF and microemulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Monosteol™ Gattefossé	Consistency agent for oily phase in topical formulations. Stability-improving agent	Non-ionic consistency/thickening agent, Stabilizer for emulsions	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Ovucire® 3460 Gattefossé	Good mechanical resistance. Enhanced spreadability of the formulation for vaginal delivery.	Unique blends with varying consistency and wetting properties adapted for vaginal pessaries	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Ovucire® WL 3264 Gattefossé	Enables fast-melting at normal temperature of the vaginal cavity.	Unique blends with varying consistency and wetting properties adapted for vaginal pessaries	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Peceol™ Gattefossé	Solubilizer for lipophilic APIs and bioavailability enhancer. Oily vehicle containing long-chain fatty acids (C18:2) for LFCS Type I (oily), Type II (SEDDS), and Type III (SMEDDS), associated with lymphatic absorption. Oily vehicle for topical formulations.	Oily vehicle, Solubilizer, Bioavailability enhancer, Component of SELF	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Plurol® Diisostearique Gattefossé	PEG-free W/O emulsifier for topical formulations Ideal for heat-sensitive API Stabilizes and improves sensorial and texture properties	W/O emulsifier for lotions and creams, Excellent for dispersions and apolar oils, Allows hot or cold process	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Precirol® ATO 5 Gattefossé Related Related Featured Product APR	Lipid Matrix for Sustained Release, Coating for Protection and Taste Masking. Oral Solid Dosage forms in Direct Compression, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization, Supercritical Fluid Extraction, Viscosity modification, Wet Granulation, Solid Lipid Nanoparticles, Nano Lipid Carriers	Lipid Matrix for Sustained Release, Coating for Protection and Taste Masking. Oral Solid Dosage forms in Direct Compression, Dry Granulation, Film Coating, Hot Melt Extrusion, Roller Compaction, Spheronization, Supercritical Fluid Extraction, Viscosity mo	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Sedefos™ 75 Gattefossé	Emulsifier for anhydrous topical formulations. Emulsifier for difficult-to-formulate emulsions (solvents and large oily phase). Stabilizes and improves sensorial and texture properties.	Inquire	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Suppocire® Series Gattefossé	Inquire	Universal bases for a wide range of manufacturing needs for suppositories and pessaries, compatible with many actives	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Tefose® 63 Gattefossé	Inquire	Non-ionic O/W emulsifier for topical and vaginal creams, High mucosal tolerance, Low-energy, one-pot processing	Get quote White Paper SDI Phase	Compare or Get quote for selected.
Transcutol® HP Gattefossé	High purity solvent for all types of dosage forms, capsules, Injectables, inhalation products, Co-solvent in SMEDDS, solutions, suspensions, Topical Penetration and Permeation enhancer	High purity solvent for all types of dosage forms, capsules, Injectables, inhalation products, Co-solvent in SMEDDS, solutions, suspensions, Topical Penetration and Permeation enhancer	Get quote White Paper SDI Phase	Compare or Get quote for selected.