Solubilizer Excipients

Solubilizer Excipients

Poorly soluble drugs are a major issue for the pharmaceutical industry. By using solubility enhancement excipients pharmaceutical formulators can increase the bioavailability of the active pharmaceutical ingredient (API). Advanced solubility enhancement excipients can help companies bring products to market faster. Developing pharmaceutical formulations with appropriate solubility will continue to be one of the key challenges of next years.

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Acconon Mixtures for Bioavailability and Emulsion
  • Functionality: Solubilizer, Emulsifier, Solvent
  • Application: Inquire
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Captex 350 Glycerol-Tricaprylate/Caprate/Laurate
  • Functionality: Solubilizer
  • Application: Inquire
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Plasdone&#8482; K-90 PVP

Plasdone™ K-90 PVP

Ashland Inc.

  • Functionality: Solubilizer, Binder
  • Application: Spray Drying, Wet Granulation, Solubilization
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Labrasol&reg; ALF

Labrasol® ALF

Gattefossé

  • Functionality: Water disperible surfactant, solubilizer and bioavailability enhancer in SMEDDS, topical penetration/permeation enhancer, able to form light foams with pump device (no gas required), low impurities guaranteed for stability and capsule compatibility
  • Application: Oral, Topical, Transdermal
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Maisine&reg; CC

Maisine® CC

Gattefossé

  • Functionality: Oily vehicle solubilizer and bioavailability enhancer for lipophilic APIs, associated with lymphatic absorption, oily vehicle for topical formulations
  • Application: Oral, Topical
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Transcutol&#174; HP

Transcutol® HP

Gattefossé

  • Functionality: High purity solvent for all types of dosage forms, capsules, injectables, co-solvent in SMEDDS, solutions, suspensions, topical penetration and permeation enhancer
  • Application: Oral, Topical, Transdermal, Parenteral
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Captisol&#174; Modified Cyclodextrin

Captisol® Modified Cyclodextrin

Ligand Pharmaceuticals

  • Functionality: Solubilizer, Increased bioavailability, Stabilizer
  • Application: Improves solubility, stability, bioavailability and dosing of APIs
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Capmul MCG and Propylyene Glycol Esters
  • Functionality: Solubilizer, Emulsifier, Solvent
  • Application: Inquire
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Caprol Polyglycerol Esters
  • Functionality: Solubilizer, Emulsifier
  • Application: Inquire
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Captex 200P

Captex 200P

ABITEC

  • Functionality: Solubilizer
  • Application: Inquire
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Captex 810D Glycerol Tricaprylate/Caprate/Linoleate
  • Functionality: Solubilizer
  • Application: Inquire
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Captex Medium Chain Esters
  • Functionality: Solubilizer, Emulsifier, Solvent
  • Application: Inquire
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Biorise Bioavailability Enhancement Technology
  • Functionality: Solubilizer
  • Application: Inquire
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Kollidon VA 64

Kollidon VA 64

BASF North America

  • Functionality: Binder
  • Application: Dry binder in tablets, capsules and granules, as a film-forming agent in tablet coatings and subcoatings, and as a film-forming agent in topical sprays. Widely used in HME processes.
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Kolliphor EL

Kolliphor EL

BASF North America

  • Functionality: Solubilizer
  • Application: Nonionic emulsifier for O-W emulsions, Solubilizer
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Kolliphor ELP

Kolliphor ELP

BASF North America

  • Functionality: Solubilizer
  • Application: For sensitive active ingredients to improve their stability
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Kolliphor RH40

Kolliphor RH40

BASF North America

  • Functionality: Solubilizer
  • Application: Solubiliser, Plasticizer for coating & polymeric matrices, Nonionic emulsifier for O-W emulsions
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Kollisolv P 124

Kollisolv P 124

BASF North America

  • Functionality: Solubilizer
  • Application: Liquid plasticizer for tablet coatings, Solvent for APIs, dispersing agent, stabilizer and co-emulsifier in semi-solid formulations
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Soluplus

Soluplus

BASF North America

  • Functionality: Binder
  • Application: Increase solubility and bioavailability, Ideal for hot melt extrusion (HME)
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Crodasol&#8482; HS HP

Crodasol™ HS HP

Croda Pharma

  • Functionality: Solubilizer, Emulsion Stabilizer
  • Application: Inquire
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Super Refined&#8482; CCMG 400
  • Functionality: Excipient, Surfactant, Self-Emulsifying Drug Delivery, Solbuilizer, Solvent
  • Application: Inquire
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Super Refined&#8482; Castor Oil
  • Functionality: Emulsifier, Solubilizer, Solvent
  • Application: Inquire
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Super Refined&#8482; DEGEE

Super Refined™ DEGEE

Croda Pharma

  • Functionality: Excipient, Penetration Enhancer, Self-Emulsifying Drug Delivery, Solubilizer, Solvent
  • Application: Inquire
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Super Refined&#8482; P35 Castor Oil
  • Functionality: Excipient, Emulsifier, Surfactant, Self-Emulsifying Drug Delivery, Solubilizer
  • Application: Inquire
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Super Refined&#8482; PEG 400
  • Functionality: Viscosity Modifier, Solvent, Solubilizer
  • Application: Inquire
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Super Refined&#8482; Polysorbate 20
  • Functionality: Excipient, Emulsifier, Plasticizer, Solubilizer, Wetting Agent
  • Application: Inquire
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Super Refined&#8482; Polysorbate 80
  • Functionality: Emulsifier, Plasticiser, Solubiliser
  • Application: Inquire
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Super Refined&#8482; Propylene Glycol
  • Functionality: Solubilizer, Emulsifier
  • Application: Inquire
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Synperonic&#8482; PE Poloxamers
  • Functionality: Solubilizer, Emulsifier, Surfactant
  • Application: Inquire
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Capryol PGMC

Capryol PGMC

Gattefossé

  • Functionality: Solubilizer, bioavailability and penetration enhancer, water insoluble W/O cosurfactant for SELF and suspensions
  • Application: Oral, Topical
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Capryol&#8482;90

Capryol™90

Gattefossé

  • Functionality: Solubilizer, bioavailability and penetration enhancer, water insoluble W/O cosurfactant for SELF and suspensions
  • Application: Oral, Topical, Transdermal, Parenteral
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Gelucire&#174; 44/14

Gelucire® 44/14

Gattefossé

  • Functionality: Solubilizer, bioavailability enhancer, and surfactant in solid dispersions and SMEDDS
  • Application: Oral
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Gelucire&#174; 48/16

Gelucire® 48/16

Gattefossé

  • Functionality: Solubilizer, bioavailability enhancer, and surfactant for poorly-soluble APIs, solid dispersions, and SMEDDS
  • Application: Oral
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Gelucire&#174; 50/13

Gelucire® 50/13

Gattefossé

  • Functionality: Solubilizer, bioavailability enhancer, and surfactant for poorly-soluble APIs in solid dispersions and SMEDDS, lipid binder in melt processes
  • Application: Oral
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Labrafac&#8482; PG

Labrafac™ PG

Gattefossé

  • Functionality: Oily phase vehicle and solubilizer
  • Application: Oral, Topical
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Labrafac&#8482; lipophile WL 1349
  • Functionality: Oily phase vehicle and solubilizer
  • Application: Oral, Topical, Rectal/Vaginal, Transdermal, Nasal, Parenteral
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Labrafil&#174; M 1944 CS

Labrafil® M 1944 CS

Gattefossé

  • Functionality: Solubilizer and bioavailability enhancer for poorly-soluble APIs, self-emulsifier in aqueous fluid, co-emulsifier in topical formulations often associated with Tefose® 63
  • Application: Oral, Topical, Rectal/Vaginal, Transdermal, Nasal, Parenteral
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Labrafil&#174; M 2125 CS

Labrafil® M 2125 CS

Gattefossé

  • Functionality: Solubilizer and bioavailability enhancer for poorly-soluble APIs, self-emulsifier in aqueous fluid
  • Application: Oral, Topical, Rectal/Vaginal, Transdermal, Nasal, Parenteral
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Labrafil&#174; M1944 CS

Labrafil® M1944 CS

Gattefossé

  • Functionality: Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancer
  • Application: Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Injectables, Topical Penetration and Permeation enhancer
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Labrasol&#174;

Labrasol®

Gattefossé

  • Functionality: Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid
  • Application: Solubilizer, Bioavailability enhancer, Surfactant in capsule filling, SMEDDS, Solutions, Suspensions, Topical Penetration and Permeation enhancer, Processing aid
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Labrasol&#174;

Labrasol®

Gattefossé

  • Functionality: Solubilizer and O/W surfactant for microemulsion. Able to form light foams with pump device (no gas required).
  • Application: Water dispersible surfactant, Solubilizer, Bioavailability enhancer, Component of SELF, Topical penetration/permeation enhancer
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LauroglycolTM 90

LauroglycolTM 90

Gattefossé

  • Functionality: Solubilizer, bioavailability and penetration enhancer, water insoluble W/O co-surfactant for SELF and suspensions
  • Application: Oral, Topical, Transdermal
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Lauroglycol&#8482; FCC

Lauroglycol™ FCC

Gattefossé

  • Functionality: Solubilizer, bioavailability and penetration enhancer, water insoluble W/O co-surfactant for SELF and suspensions
  • Application: Oral, Topical, Transdermal
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Peceol&#8482;

Peceol™

Gattefossé

  • Functionality: Oily vehicle solubilizer and bioavailability enhancer for lipophilic APIs, associated with lymphatic absorption, oily vehicle for topical formulations
  • Application: Oral, Topical
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Plurol&#174; Oleique CC 497
  • Functionality: Solubilizer and bioavailability enhancer for poorly-soluble APIs, cosurfactant in microemulsions, viscosity enhancer for capsule filling
  • Application: Oral, Topical
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Transcutol&#174; P

Transcutol® P

Gattefossé

  • Functionality: High purity solvent, topical penetration and permeation enhancer, co-solvent in SMEDDS, solutions, suspensions
  • Application: Oral, Topical, Transdermal, Parenteral
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Nisso HPC &#8211; hydroxypropyl cellulose
  • Functionality: Coating Systems, Viscosity Modifier, Solubilizer, Controlled Release, Binder, Emulsifier, Plasticizer
  • Application: Inquire
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KLEPTOSE&#174; Linecaps
  • Functionality: solubilizer, stabilizer and taste-making agent
  • Application: Pharmaceutical and nutraceutical applications including swallowable tablets, chewable tablets, effervescent tablets, lozenges, hard capsules, soft capsules, coatings, orally dissolving films, blends, granules, pellets premix, medicated confectionary, syrups, suspensions, liquids, creams, paste and semi-solids.
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KLEPTOSE&#174; PARENTERAL GRADE
  • Functionality: improves drug solubility and stability against light or oxidation by molecular encapsulation
  • Application: Encapsulating agent
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